According to the World Health Organization, attention deficit hyperactivity disorder (ADHD) is estimated to affect approximately 5% of children worldwide and 2.5% of adults. This disorder manifests as inattention, hyperactivity, impulsivity, and difficulty focusing, and it can greatly influence a person's academic and social functioning.
Although ADHD has been recognized to have a genetic basis, the specific genes implicated have been challenging to identify. However, recent advancements have brought us closer to unraveling this mystery.
Israeli scientists have successfully pinpointed a particular gene, CDH2, which seems to be significantly involved in the progression of ADHD. The CDH2 gene encodes N-cadherin, a protein crucial for facilitating brain synapse activity and formation.
Through their investigation, the researchers discovered that a mutation in CDH2 disrupts this activity, influencing molecular pathways and dopamine levels within two specific brain regions associated with ADHD: the ventral midbrain and the prefrontal cortex.
Researchers from Ben-Gurion University of the Negev and Soroka-University Medical Center conducted the study, which was published in the peer-reviewed academic journal Nature Communications.
Fonte: https://www.thebrighterside.news/